Scientists gave old male mice a special compound called 17-alpha-estradiol in their food starting at 20 months old (roughly equivalent to late middle age in humans), and the mice lived about 11% longer than mice that didn't get the compound.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Cohort Study

Animal

2021 May

The study directly confirms the claim - when male mice got 17-α-estradiol in their food starting at 20 months old, their median lifespan increased by exactly 11% with a p-value of 0.007, which is statistically significant.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Score: 13

DOI: 10.1111/acel.13328

Similar Assertions

Scientists fed old male mice a special chemical called 17-α-estradiol and found they lived about 19% longer than mice that didn't get the chemical.

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97%

Scientists gave old mice a compound called 17-alpha-estradiol when they were already pretty old (like 50-60 human years), and it still made them live 11% longer on average.

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92%

A special form of estrogen called 17-alpha-estradiol helped male mice live longer, but female mice given the same amount didn't get any lifespan benefit.

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92%

Giving male mice a special compound called 17-α-estradiol when they were middle-aged (16 months) helped them live about 7% longer, specifically extending their maximum lifespan.

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89%

A special form of estrogen called 17-alpha-estradiol helped male mice live longer when they started taking it in middle age - about 19% longer if started at 16 months old and 11% longer if started at 20 months old. It also increased their maximum lifespan by 7%. But female mice didn't get any lifespan benefit from it at all.

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89%