The Claim
Administration of 17-α-estradiol at 14.4 parts per million in the diet to male UM-HET3 mice beginning at 20 months of age resulted in an 11% increase in median lifespan (p=0.007), demonstrating efficacy when treatment is initiated in late life.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Scientists gave old male mice a special compound called 17-alpha-estradiol in their food starting at 20 months old (roughly equivalent to late middle age in humans), and the mice lived about 11% longer than mice that didn't get the compound.
See the scientific wording
17-α-estradiol (14.4 ppm in diet) administered to male UM-HET3 mice beginning at 20 months of age (early old age) was associated with an 11% increase in median lifespan (p=0.007), demonstrating efficacy even when treatment is initiated late in life
What the research says
1 studyThe study directly confirms the claim - when male mice got 17-α-estradiol in their food starting at 20 months old, their median lifespan increased by exactly 11% with a p-value of 0.007, which is statistically significant.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.