Even when the body is in starvation mode, one specific part of the muscle growth system (4E-BP1) becomes more active — which is confusing because other parts are shutting down.

Pro

Against

Evidence from Studies

Supporting (1)

Community contributions welcome

Protein synthesis signaling in skeletal muscle is refractory to whey protein ingestion during a severe energy deficit evoked by prolonged exercise and caloric restriction

Randomized Controlled Trial

Human

2019 Apr

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Protein synthesis signaling in skeletal muscle is refractory to whey protein ingestion during a severe energy deficit evoked by prolonged exercise and caloric restriction

Score: 32

DOI: 10.1038/s41366-018-0174-2

Similar Assertions

When you lift weights, a specific protein in your muscles (4E-BP1) temporarily stops being activated in one way, even though another related protein (mTOR) stays just as active as before—this suggests that mTOR might be controlling 4E-BP1 through a different, hidden method.

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