The Claim
In rat skeletal muscle, chronic resistance exercise training consisting of 4 sessions over 2 weeks is associated with a 38% increase in myofibrillar protein synthesis rates (from 2.6% to 3.3% per day) despite a 50-75% decrease in basal mTORC1 signaling markers p-S6K1 and p-S6, indicating that elevated protein turnover can occur independently of canonical anabolic pathway activation.
What the research says
Roughly balanced
Support and challenge are close. The picture may shift as more studies come in.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In rats, lifting weights for two weeks made their muscles build more protein even though the usual muscle-building signals in their bodies went down. This shows muscles can grow without needing those normal signals.
See the scientific wording
In rat skeletal muscle, chronic resistance exercise training consisting of 4 sessions over 2 weeks is associated with a 38% increase in myofibrillar protein synthesis rates (from 2.6% to 3.3% per day) despite a 50-75% decrease in basal mTORC1 signaling markers p-S6K1 and p-S6, indicating that elevated protein turnover can occur independently of canonical anabolic pathway activation.
What the research says
1 studyThe study did the same exercise training in rats as described in the claim and found that muscle protein building went up even though the usual growth signals went down, which backs up the claim.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
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