In people around 78 years old who have Alzheimer’s, the drop in blood flow to the brain and body isn’t because they’re less active, have less muscle, burn fewer calories at rest, or have different levels of carbon dioxide in their blood.

43

Pro

0

Against

Evidence from Studies

Supporting (1)

43

Community contributions welcome

43

Impact of Nitric Oxide Bioavailability on the Progressive Cerebral and Peripheral Circulatory Impairments During Aging and Alzheimer's Disease

Cross-Sectional Study

Human

2018

This study found that as Alzheimer’s gets worse, blood flow drops because of a lack of nitric oxide — not because people are less active, have less muscle, or breathe differently. So the claim that those other things don’t explain the problem is supported.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Impact of Nitric Oxide Bioavailability on the Progressive Cerebral and Peripheral Circulatory Impairments During Aging and Alzheimer's Disease

Score: 43

DOI: 10.3389/fphys.2018.00169

Similar Assertions

In people around 78 years old, the worse their Alzheimer’s gets, the less blood flows to their brain and major arteries in their neck and leg — and this isn’t just because they’re older, less active, or have less muscle.

43

0

90%

When people with Alzheimer’s disease get worse, their blood vessels don’t open up as well in response to moving their legs, and this is linked to less blood flow in their brain and body.

43

0

73%

People with Alzheimer's have blood vessels that don't respond as well to signals that make them open up, even after taking a supplement called nitrate—which normally helps blood flow better—compared to older healthy people and young people.

38

0

72%