Exercise makes muscles better at using insulin and the liver produce less sugar—but those improvements don’t match up with changes in chemerin levels, meaning chemerin isn’t the main reason exercise...

When older, overweight people do intense exercise for 12 weeks, a fat-related chemical in their blood called chemerin goes down—and that drop is linked to losing belly fat, better cholesterol numbers, and less insulin being released after eating sugar.

When older, overweight people lose belly fat from exercise, a chemical called chemerin in their blood also drops—so chemerin might be a sign that their fat tissue is getting healthier.

After doing intense exercise for 12 weeks, older overweight people’s pancreases release less insulin right after eating sugar—and that drop matches a drop in a chemical called chemerin, hinting chemerin might tell the pancreas how much insulin to make.

When older overweight people exercise and their blood chemerin drops, their bad fats (cholesterol and triglycerides) also go down—so chemerin might be connected to how the body handles fats.

Doing a mix of walking, strength, and balance exercises three times a week for two months likely improves how the body uses insulin in older adults who are overweight, reducing diabetes risk. This finding is from the abstract summary - full study details were not available