mechanistic
Analysis v1
Contested
If your red blood cells live longer, they soak up more sugar over time, which can make your HbA1c blood test go up — even if your average blood sugar hasn't actually changed.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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The study shows that when red blood cells live longer, they have more time to absorb sugar, which raises HbA1c levels even if blood sugar hasn’t changed much.
Contradicting (1)
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Community contributions welcome
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Red Blood Cell Lifespan < 74 Days Can Clinically Reduce Hb1Ac Levels in Type 2 Diabetes
Cohort Study
Human
2022 Oct 19The study looked at how long red blood cells live and whether that changes HbA1c levels. It found that longer-lived cells didn’t lead to higher HbA1c, which goes against the idea that living longer makes them absorb more sugar and raise HbA1c.
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.