The Claim
Isolated rat adipocytes express a single class of high-affinity endothelin-1 receptors with a binding affinity (Kd) of 350 pM and a density of 69,000 sites per cell.
What the research says
Roughly balanced
Support and challenge are close. The picture may shift as more studies come in.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Rat fat cells contain one type of receptor that binds endothelin-1 with high affinity, at a concentration of 350 picomolar and 69,000 receptors per cell.
See the scientific wording
Isolated rat adipocytes express a single class of high-affinity endothelin-1 receptors with a binding affinity (Kd) of 350 pM and a density of 69,000 sites per cell.
Fat cells in rats have special receptors that tightly bind a molecule called endothelin-1. When endothelin-1 attaches to these receptors, it triggers a signal inside the cell that blocks insulin from making the cell take up glucose, even though insulin can still bind to its own receptor.
What the research says
1 studyStudy: Endothelin-1 inhibits insulin-stimulated glucose uptake in isolated rat adipocytes.
This study found that fat cells in rats have special spots (receptors) that grab onto a molecule called endothelin-1, and it measured exactly how many spots there are and how tightly they hold on — just like the claim said.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.