The Claim
Human abdominal and gluteal subcutaneous adipose tissues exhibit distinct gene expression profiles, with multiple homeobox (HOX) genes, including HOXA3, HOXA5, HOXB8, and HOXC8, consistently down-regulated in gluteal fat compared to abdominal fat in both men and women, independent of BMI, suggesting these developmental genes contribute to depot-specific cellular identity and functional differences.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Fat tissue under the skin in the abdomen and buttocks has different patterns of gene activity, with certain genes involved in body development being less active in buttock fat than in abdominal fat, regardless of body weight.
See the scientific wording
Human abdominal and gluteal subcutaneous adipose tissues exhibit distinct gene expression profiles, with multiple homeobox (HOX) genes, including HOXA3, HOXA5, HOXB8, and HOXC8, consistently down-regulated in gluteal fat compared to abdominal fat in both men and women, independent of BMI, suggesting these developmental genes contribute to depot-specific cellular identity and functional differences.
What the research says
1 studyStudy: Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots.
Scientists found that the fat around your hips and butt has different active genes than the fat around your belly — especially genes that help shape the body during development. These differences exist in both men and women, no matter their weight.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.