The Claim
Higher sex hormone-binding globulin (SHBG) levels mediate 24.74% of the protective effect of gluteofemoral adipose tissue on polycystic ovary syndrome risk by reducing bioavailable testosterone, thereby contributing to lower polycystic ovary syndrome risk.
What the research says
Not yet evaluated
We are still looking at what the research says.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Increased levels of sex hormone-binding globulin, which is influenced by fat stored in the hips and thighs, reduce the amount of free testosterone in the body, and this mechanism accounts for about 25% of why this fat distribution is linked to a lower risk of polycystic ovary syndrome.
See the scientific wording
Higher sex hormone-binding globulin (SHBG) levels mediate 24.74% of the protective effect of gluteofemoral adipose tissue on polycystic ovary syndrome risk, indicating that increased SHBG reduces bioavailable testosterone and contributes to lower PCOS risk.
What the research says
1 studyThis study shows that fat stored around the hips and thighs helps protect against PCOS, and one reason is that it increases a protein (SHBG) that lowers harmful testosterone levels — exactly what the claim says.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.