mechanistic
Analysis v1
Strong Support
Giving mice a supplement called L-carnitine every day makes artery disease about twice as bad, but if you wipe out their gut bacteria with antibiotics, that effect goes away — meaning the gut bugs are behind the harm.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Cohort Study
Human
2013 MayThe study shows that when mice eat extra L-carnitine, they get more artery disease, but only if their gut bacteria are active. If the bacteria are wiped out with antibiotics, the harm goes away.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.