The Claim

Fisetin at 600 ppm, SG1002 at 240 ppm, dimethyl fumarate at 120 ppm, mycophenolic acid at 6.7 ppm, and 4-phenylbutyrate at 1000 ppm did not significantly extend lifespan in either male or female UM-HET3 mice at the doses and schedules tested.

Source: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
13score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Description
1 study reviewed
In plain English

Scientists tested five different compounds at specific doses in mice and found that none of them made the mice live longer compared to mice that didn't get the compounds.

See the scientific wording

Fisetin at 600 ppm, SG1002 at 240 ppm, dimethyl fumarate at 120 ppm, mycophenolic acid at 6.7 ppm, and 4-phenylbutyrate at 1000 ppm did not significantly extend lifespan in either male or female UM-HET3 mice at the doses and schedules tested

What the research says

1 study

  1. Study: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

    The study tested the exact same five compounds at the exact same doses in the same type of mice as mentioned in the claim, and found that none of them extended lifespan - exactly what the claim says happened.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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