Scientists tested five different compounds at specific doses in mice and found that none of them made the mice live longer compared to mice that didn't get the compounds.

13

Pro

0

Against

Evidence from Studies

Supporting (1)

13

Community contributions welcome

13

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Cohort Study

Animal

2024 Feb

The study tested the exact same five compounds at the exact same doses in the same type of mice as mentioned in the claim, and found that none of them extended lifespan - exactly what the claim says happened.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Score: 13

DOI: 10.1007/s11357-023-01011-0