For adults who aren't diabetic but carry extra weight, a weekly injection of semaglutide (2.4 mg) plus healthy lifestyle changes led to nearly 15% weight loss over a year and a half—way more than lifestyle changes alone.

People with obesity and another health issue who got a weekly shot of semaglutide plus behavioral therapy lost about 17 kg on average after a year and a half — way more than those who got a placebo.

Taking a weekly injection called semaglutide along with healthy eating and exercise can help people with obesity or overweight lose about 15% of their body weight in a year—much more than people who just take a sugar pill.

If you're an adult with extra weight but don't have diabetes, taking a weekly 2.4 mg shot of semaglutide for about a year and a half can help you lose around 13 kg of fat, including some deep belly fat, while mostly keeping your muscle — even though you might lose a little muscle too, the fat loss is much bigger.

A weekly shot called semaglutide helped people with obesity and bad knee arthritis lose way more weight—about 13.7% of their body weight—compared to a fake shot that only led to 3.2% loss, and that weight loss might help their joint pain feel better.

Even if you don’t have diabetes, if you’re overweight and have heart disease, a weekly shot of semaglutide can cut your risk of heart attack or stroke by 1 in 5 — and this benefit starts before you lose much weight.