The Claim

In hemodialysis patients with existing vascular calcification, daily oral supplementation of 180 μg of vitamin K2 for one year is associated with a 21.3% reduction in dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP) levels and a 15.1% reduction in aortic calcification as measured by Agatston score.

Source: #5745 CORRELATION BETWEEN MATRIX GLA PROTEIN LEVEL AND EFFECT OF VITAMIN K2 THERAPY ON VASCULAR CALCIFICATION IN HEMODIALYSIS PATIENTS

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
49score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

In patients undergoing hemodialysis with vascular calcification, taking 180 micrograms of vitamin K2 daily for one year is associated with a 21.3% decrease in dp-ucMGP levels and a 15.1% decrease in aortic calcification measured by Agatston score.

See the scientific wording

In hemodialysis patients with existing vascular calcification, daily oral supplementation of 180 μg of vitamin K2 for one year is associated with a 21.3% reduction in dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP) levels and a 15.1% reduction in aortic calcification as measured by Agatston score, suggesting vitamin K2 may slow the progression of vascular calcification in this population.

Why this might work

Vitamin K2 enables a protein in blood vessel walls to bind calcium and stop it from forming hard deposits. Without enough vitamin K2, this protein stays inactive and cannot block calcium buildup. When vitamin K2 is present, it turns the protein on, allowing it to trap calcium and prevent arteries from hardening.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: #5745 CORRELATION BETWEEN MATRIX GLA PROTEIN LEVEL AND EFFECT OF VITAMIN K2 THERAPY ON VASCULAR CALCIFICATION IN HEMODIALYSIS PATIENTS

    For people on dialysis with calcium buildup in their arteries, taking a daily vitamin K2 pill for a year lowered a blood marker of vitamin K deficiency and also reduced the amount of calcium in their arteries—meaning it may help slow down the hardening of their blood vessels.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.