For people who already regularly lift weights, doing more sets per week does not reliably lead to more muscle growth than doing fewer sets.
Mechanism
Synthesis from 1 study
When people lift weights for a long time, their muscles stop responding as strongly to the extra stress of more sets. The signals that tell muscles to grow get weaker, so adding more workouts doesn’t make them grow any bigger — they’ve already adapted.
Most probable mechanism
When someone has been lifting weights for a while, their muscles become less responsive to the signals that tell them to grow bigger. Adding more workouts doesn’t help much because the muscles don’t react to the extra stress like they did when they were new to training.
Chronic resistance training reduces the sensitivity of mTORC1 signaling pathways to mechanical and nutrient stimuli in skeletal muscle.
Diminished mTORC1 activation leads to reduced rates of muscle protein synthesis in response to increased training volume.
Muscle hypertrophy plateaus because the cellular machinery for building new contractile proteins is no longer sufficiently stimulated by additional sets.
Evidence from Studies
Supporting (1)
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Contradicting (0)
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