For middle-aged and older adults with high 'bad' cholesterol and certain gene versions, taking 2000 mg of omega-3 fish oil every day for three months can lower their bad cholesterol and triglycerides more than a placebo — and their genes might make this effect stronger.

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Evidence from Studies

Supporting (1)

69

Community contributions welcome

69

Evaluating the Impact of Omega-3 Fatty Acid (SolowaysTM) Supplementation on Lipid Profiles in Adults with PPARG Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial

Randomized Controlled Trial

Human

2023 Dec 27

People with certain gene versions responded much better to omega-3 fish oil pills — their bad cholesterol and triglycerides dropped a lot — while people without those gene versions saw almost no change. This means your genes can affect how well omega-3s work for your heart.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Evaluating the Impact of Omega-3 Fatty Acid (SolowaysTM) Supplementation on Lipid Profiles in Adults with PPARG Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial

Score: 69

DOI: 10.3390/nu16010097

Similar Assertions

People with a specific gene variation called PPARG may see much better results from taking omega-3 supplements—like lower bad cholesterol and triglycerides—than people without that gene variation.

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93%

People with a specific gene variation and high 'bad' cholesterol tend to have even higher cholesterol levels than others, and their bodies might respond better to omega-3 supplements to help lower it.

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84%

Taking 2000 mg of omega-3s daily for three months doesn’t change your good cholesterol, total cholesterol, or inflammation markers — so if it helps lower bad cholesterol and triglycerides, it’s not because it’s reducing overall inflammation or affecting all types of fats in your blood.

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81%

Taking 2000 mg of omega-3 fish oil daily for three months doesn't lower a common marker of body inflammation called hsCRP, no matter what your genes say. So, if omega-3s help your cholesterol, it's probably not because they're calming down inflammation.

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73%