For adults who are overweight, have heart disease, and early kidney problems but not diabetes, taking a weekly semaglutide shot might help their kidneys work better over two years compared to a...

For adults who are overweight, have heart disease, but don’t have diabetes, taking a weekly semaglutide shot might help slow down how fast their kidneys lose function each year.

In people with type 2 diabetes and kidney disease, a weekly injection of semaglutide at 1.0 mg slows the rate at which kidney function declines by 1.16 mL/min/1.73m² per year compared to no treatment, based on a median follow-up of 3.4 years.

The kidney benefits from taking a weekly semaglutide shot for weight and heart health probably aren't just because it lowers blood sugar or blood pressure — there might be other ways it's helping the kidneys.

In adults with type 2 diabetes and advanced kidney disease, a weekly injection of semaglutide at 1.0 mg lowers the combined risk of kidney failure, severe loss of kidney function, or death from heart or kidney causes by 24% compared to a placebo over about 3.4 years.

For people with type 2 diabetes and kidney problems, taking a weekly semaglutide shot might help slow down how fast their kidneys get worse.