Among adults with obesity, social isolation is linked more strongly to the risk of death from any cause than other factors like loneliness, depression, or unhealthy behaviors, and is ranked as the...
Mechanism
Synthesis from 1 study
When someone with obesity is cut off from others for a long time, their body stays in high alert, releasing stress hormones that make fat tissue release harmful chemicals. This over time damages blood vessels and organs, raising the risk of early death—even more than poor diet or lack of exercise.
Most probable mechanism
When someone is cut off from other people for a long time, their body stays in a state of stress, which causes more stress hormones to circulate. These hormones make fat tissue release harmful chemicals, raise blood sugar, and make the immune system overreact, which over time damages organs and increases the chance of dying early.
Chronic social isolation increases activity in the hypothalamic-pituitary-adrenal axis, elevating circulating cortisol levels
Elevated cortisol promotes lipolysis in visceral adipose tissue and increases free fatty acid flux to the liver
Increased free fatty acids and cortisol stimulate hepatic gluconeogenesis and induce insulin resistance
Adipose tissue inflammation increases due to macrophage infiltration and pro-inflammatory cytokine secretion (e.g., IL-6, TNF-α)
Systemic inflammation and metabolic dysregulation accelerate atherosclerosis, endothelial dysfunction, and organ damage
Evidence from Studies
Supporting (1)
Community contributions welcome
Improvement of Social Isolation and Loneliness and Excess Mortality Risk in People With Obesity
Contradicting (0)
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