For people with type 2 diabetes, having higher levels of folate (a B vitamin) in their blood doesn’t seem to make them more likely to die from heart disease, compared to people with moderate folate levels.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes

Cohort Study

Human

2022 Jan 4

This study found that adults with type 2 diabetes who have high levels of folate (above 19.5 ng/mL) don’t have a higher chance of dying from heart disease compared to those with moderate levels — so high folate isn’t harmful in this group.

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes

Score: 59

DOI: 10.1001/jamanetworkopen.2021.46124

Similar Assertions

People with type 2 diabetes who have low levels of folate (a B vitamin) in their blood are 43% more likely to die from heart disease than those with moderate folate levels—so low folate might be linked to worse heart outcomes.

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97%

In people with type 2 diabetes, low folate might raise the risk of dying from heart disease because it leads to higher homocysteine, but high vitamin B12 affects heart disease risk on its own, no matter what homocysteine levels are.

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83%