Strong Opposition
quantitative
Analysis v2
History

For women who already train regularly, increasing leg workouts from 22 to 34 sets per week for 12 weeks does not lead to greater strength gains in the leg press compared to 22 sets, suggesting that...

0
Pro
47
Against

Mechanism

Synthesis from 1 study

How it works

When trained women do more than about 22 leg workouts a week, their muscles can’t build new proteins any faster — so even doing 30 or 34 sets doesn’t make them stronger, as shown in 10.1080/02640414.2025.2459003.

Most probable mechanism

In Simple Terms

When trained women do a lot of leg workouts each week, their muscles stop getting stronger with more sets because the body can only build new muscle proteins at a certain speed — after a point, adding more workouts doesn’t speed this up, so strength stops increasing even if they do more sets, as seen in 10.1080/02640414.2025.2459003.

Causal chain
1

Resistance training triggers mTORC1 signaling in skeletal muscle, initiating muscle protein synthesis.

Indirect evidence only
which leads to
2

With increasing weekly training volume, the rate of muscle protein synthesis rises initially but reaches a maximum capacity beyond approximately 22 sets per week, limiting further net muscle accretion.

Indirect evidence only
which leads to
3

Once protein synthesis plateaus, the balance between muscle building and breakdown stabilizes, resulting in no further gains in strength despite additional volume.

Indirect evidence only

Evidence from Studies

Supporting (0)

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No supporting evidence found

Contradicting (1)

47

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Gold Standard Evidence Needed

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Science Topic

Does increasing resistance training volume beyond 22 sets per week improve leg press strength in trained women?

Supported
Leg Press Training

We analyzed the available evidence and found that for trained women, increasing leg training volume from 22 to 34 sets per week over 12 weeks does not appear to lead to greater improvements in leg press strength compared to sticking with 22 sets [1]. This single assertion, which we’ve reviewed so far, suggests that beyond a certain point, adding more sets may not translate to stronger gains in this specific movement. The evidence we’ve reviewed leans toward the idea that there may be a volume threshold for strength gains in trained women, and exceeding 22 sets per week for the leg press doesn’t seem to push results further. We don’t know if this applies to other exercises, different training durations, or women at other experience levels. The data we have is limited to one study-like assertion, and we haven’t seen any evidence that contradicts this finding. It’s possible that for women who are already regularly training, the body adapts to a certain workload, and adding more volume doesn’t create additional stimulus for strength growth — or may even interfere with recovery. But without more studies, we can’t say whether this holds true across different populations or training styles. What this means in practice: if you’re a trained woman doing 22 sets per week of leg press work, adding more sets may not help you get stronger — at least not based on what we’ve seen so far. It might be more useful to focus on improving form, increasing intensity, or allowing better recovery rather than simply doing more sets.

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