For women who already train regularly, increasing leg workouts from 22 to 34 sets per week for 12 weeks does not lead to greater strength gains in the leg press compared to 22 sets, suggesting that...
Mechanism
Synthesis from 1 study
When trained women do more than about 22 leg workouts a week, their muscles can’t build new proteins any faster — so even doing 30 or 34 sets doesn’t make them stronger, as shown in 10.1080/02640414.2025.2459003.
Most probable mechanism
When trained women do a lot of leg workouts each week, their muscles stop getting stronger with more sets because the body can only build new muscle proteins at a certain speed — after a point, adding more workouts doesn’t speed this up, so strength stops increasing even if they do more sets, as seen in 10.1080/02640414.2025.2459003.
Resistance training triggers mTORC1 signaling in skeletal muscle, initiating muscle protein synthesis.
With increasing weekly training volume, the rate of muscle protein synthesis rises initially but reaches a maximum capacity beyond approximately 22 sets per week, limiting further net muscle accretion.
Once protein synthesis plateaus, the balance between muscle building and breakdown stabilizes, resulting in no further gains in strength despite additional volume.
Evidence from Studies
Supporting (0)
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Contradicting (1)
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Does increasing the resistance-training volume lead to greater gains? The effects of weekly set progressions on muscular adaptations in females
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