Eating too much fructose—like the sugar in soda and sweetened foods—may cause a protein in your liver to become overactive, which blocks insulin from doing its job, making your liver less responsive to insulin.

1

Pro

0

Against

Evidence from Studies

Supporting (1)

1

Community contributions welcome

1

Fructose and hepatic insulin resistance

Narrative Review

Human

2020 Aug

This study shows that eating too much fructose (like in sugary drinks) makes a liver enzyme called PTP1B more active, which blocks insulin from working properly — leading to insulin resistance.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Fructose and hepatic insulin resistance

Score: 1

DOI: 10.1080/10408363.2019.1711360

Similar Assertions

Eating too much fructose—like the sugar in soda and candy—might mess up how your liver responds to insulin, even if you don’t gain weight or eat more calories overall.

1

0

82%

Eating too much fructose over a long time can mess up how your liver responds to insulin, making it harder for your body to control blood sugar, which can lead to type 2 diabetes and heart problems.

1

0

78%

Eating a lot of fructose (like in sugary drinks) might turn up the activity of certain liver enzymes that process sugar and make fat, especially in people who already have metabolic problems like obesity or diabetes.

1

0

78%

Eating too much fructose—like the sugar in soda and sweetened snacks—may slow down your liver’s ability to burn fat, which can lead to fat buildup and make your body less responsive to insulin.

1

0

78%

Eating too much fructose over a long time can mess up how your liver responds to insulin, leading to fat buildup and higher chances of getting diabetes-related problems and clogged arteries.

1

0

77%