Genetic ablation of p16-expressing cells improves tissue function and extends lifespan in mice.

Study: Intermittent Hypoxia Mimicking Sleep Apnea Induces Systemic and Tissue Specific Epigenetic Changes and p16-Mediated Cellular Senescence Underlying Vascular Dysfunction

Scientists removed old, damaged cells (that make p16 protein) from mice and found their blood pressure dropped and heart blood flow improved. This suggests removing these cells helps the body work better, which is a key part of living longer.

Study: Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Scientists removed a type of old, damaged cell (p16+) from mice and found that female mice became stronger and had healthier livers — suggesting these cells make aging worse. Removing them helped, so the idea that getting rid of these cells can improve health and maybe even extend life is supported.

Study: Genetic Ablation of p16 Mitigates Premature Osteoporosis Induced by PTHrP Nuclear Localization Sequence and C-terminal Deletion through Inhibition of Cellular Senescence.

Scientists removed a specific type of aging cell (p16-expressing cells) from mice with a bone problem, and the mice lived longer and had stronger bones. This shows that getting rid of these cells can help animals stay healthier and live longer.