The Claim

In females, erythrocyte creatine levels are significantly higher in those who have undergone menarche (1.64 ± 0.43 µmol/g Hb) compared to those who have not (1.23 ± 0.23 µmol/g Hb, p = 0.004), with no significant difference in HbA1c between the groups, suggesting a potential association between menarche and elevated erythrocyte creatine independent of glycemic control.

Source: Elevation of erythrocyte creatine post-puberty unrelated to erythrocyte lifespan: Implications from the lack of correlation between HbA1c and erythrocyte creatine.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
36score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

Girls who have started their periods tend to have higher levels of creatine in their red blood cells compared to those who haven’t, and this doesn’t seem to be because of differences in blood sugar control.

See the scientific wording

Erythrocyte creatine levels are higher in females who have started menstruation (1.64 ± 0.43 µmol/g Hb) compared to those who have not (1.23 ± 0.23 µmol/g Hb, p = 0.004), indicating a potential link between menarche and elevated EC independent of HbA1c, which showed no significant difference between these groups.

What the research says

1 study

  1. Study: Elevation of erythrocyte creatine post-puberty unrelated to erythrocyte lifespan: Implications from the lack of correlation between HbA1c and erythrocyte creatine.

    The study found that girls who started their periods have higher levels of a blood marker called erythrocyte creatine than those who haven’t, with no difference in blood sugar markers, which supports the claim.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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