Giving a common antioxidant drug called Tempol to older female rats with high blood pressure did not lower their blood pressure, whether they ate a low-salt or high-salt diet.

Scientific Claim

Tempol treatment at 30 mg/kg/day does not affect mean arterial pressure in 20-month-old female spontaneously hypertensive rats on either low-salt or high-salt diets, with measurements of 179±5 and 178±5 mm Hg respectively.

Original Statement

“Tempol treatment had no effect on MAP in either group of female SHR (C+T: 179±5; HSD+T: 178±5 mm Hg).”

From study:Blood Pressure in Old Female SHR is not Salt Sensitive and Tempol Fails to Decrease Blood Pressure during High Salt Intake

Evidence Quality Assessment

Claim Status

unclear

Study Design Support

Design cannot support claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

Based on abstract only - full methodology not available to verify

Evidence from Studies

Supporting (1)

Blood Pressure in Old Female SHR is not Salt Sensitive and Tempol Fails to Decrease Blood Pressure during High Salt Intake

Randomized Controlled Trial

Animal

Contradicting (0)

No contradicting evidence found

Source Study

Blood Pressure in Old Female SHR is not Salt Sensitive and Tempol Fails to Decrease Blood Pressure during High Salt Intake

Score: 11

DOI: 10.1096/fasebj.30.1_supplement.963.6

Similar Assertions

When given a drug called acetazolamide, Tempol lowers blood pressure in older female rats with high blood pressure.

80%

After eating a high-salt diet for several weeks, older female rats with high blood pressure had similar blood pressure levels as those on a low-salt diet, around 178 mm Hg in both groups.

72%

In older female rats with high blood pressure, starting blood pressure was similar whether they ate a normal low-salt diet or a high-salt diet, with numbers around 174 and 168 mm Hg.

72%