Salt, Drugs, and Blood Pressure in Rats
Blood Pressure in Old Female SHR is not Salt Sensitive and Tempol Fails to Decrease Blood Pressure during High Salt Intake
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Antioxidants don't lower blood pressure in female rats despite high oxidative stress levels
Contradicts the assumption that oxidative stress directly causes hypertension in all cases, especially since females had similar or higher oxidative stress markers than males where antioxidants work
Practical Takeaways
Don't expect antioxidant supplements to lower blood pressure in women based on this study
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Antioxidants don't lower blood pressure in female rats despite high oxidative stress levels
Contradicts the assumption that oxidative stress directly causes hypertension in all cases, especially since females had similar or higher oxidative stress markers than males where antioxidants work
Practical Takeaways
Don't expect antioxidant supplements to lower blood pressure in women based on this study
Publication
Journal
The FASEB Journal
Year
2016
Authors
C. Dalmasso, R. Maranon, Chetan N. Patil, J. Reckelhoff
Related Content
Claims (6)
Processed foods contain engineered combinations of high sodium and refined carbohydrates, which together cause acute plasma volume expansion and chronic hormonal sodium retention, leading to sustained hypertension.
In older female rats with high blood pressure, starting blood pressure was similar whether they ate a normal low-salt diet or a high-salt diet, with numbers around 174 and 168 mm Hg.
After eating a high-salt diet for several weeks, older female rats with high blood pressure had similar blood pressure levels as those on a low-salt diet, around 178 mm Hg in both groups.
Giving a common antioxidant drug called Tempol to older female rats with high blood pressure did not lower their blood pressure, whether they ate a low-salt or high-salt diet.
When given a drug called acetazolamide, Tempol lowers blood pressure in older female rats with high blood pressure.