When scientists blocked a fat-burning enzyme in overweight mice, their belly fat dropped by three-quarters, fat in their blood fell nearly half, and their livers stored way less fat—suggesting that slowing down fat breakdown might help prevent fat from building up in the wrong places and make metabolism healthier.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

13

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Cohort Study

Animal

2017 Mar 22

Scientists gave mice a drug that stops fat breakdown in fat tissue, and the mice got less fat in their liver and blood, and became healthier — just like the claim said.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Score: 13

DOI: 10.1038/ncomms14859

Similar Assertions

Giving a special drug to overweight mice on a fatty diet lowers their insulin levels by 71% and helps their bodies use insulin better—without making them lose weight.

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80%

When mice eat a lot of fat and are given a special drug that blocks a fat-breaking enzyme, their livers get less inflamed and scarred—like turning down the volume on liver damage.

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13

76%

When scientists block a fat-burning enzyme called ATGL with a drug in mice, their hearts don’t get fatty or stop working—unlike when the enzyme is missing from birth, which causes serious heart problems.

13

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70%