The Claim
Oral administration of MF-300 at 10 mg/kg every other day for 12 weeks increases maximal muscle force by 32% and specific force by 11% in aged C57BL/6J mice (90–92 weeks old), independent of changes in muscle mass, indicating that inhibition of 15-PGDH enhances intrinsic contractile properties of aged fast-twitch muscle fibers.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In aged mice, taking MF-300 by mouth every other day for 12 weeks increases muscle strength by 32% and force per unit of muscle mass by 11%, without increasing muscle size, showing that blocking the enzyme 15-PGDH improves the inherent contractile ability of fast-twitch muscle fibers.
See the scientific wording
Oral administration of MF-300 at 10 mg/kg every other day for 12 weeks significantly increases maximal muscle force by 32% and specific force (force per unit mass) by 11% in aged C57BL/6J mice (90–92 weeks old), independent of changes in muscle mass, suggesting that inhibition of 15-PGDH may enhance intrinsic contractile properties of aged fast-twitch muscle fibers.
A pill blocks an enzyme that breaks down a signaling molecule called PGE2. More PGE2 builds up in old muscle, which makes the muscle fibers contract more powerfully by improving how calcium moves inside the cell and how efficiently the contractile proteins use energy. This makes the muscle stronger without getting bigger.
What the research says
1 studyGiving old mice a pill called MF-300 made their muscles stronger without making them bigger, meaning the muscles themselves got better at contracting—just like the claim said.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.