Giving cold-exposed rats a compound called TPY1, which blocks the TSH receptor, lowers their elevated T3 levels and reduces the production of key proteins involved in thyroid hormone synthesis.

Evidence from Studies

Supporting (1)

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Thyroid Hormone Levels and Expression of Genes Involved in Regulation of Thyroid System Activity in Male Rats Exposed to Prolonged Low Temperatures, and the Effect of a Thyroid-Stimulating Hormone Receptor Antagonist on These Parameters

Cohort Study

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Contradicting (0)

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No contradicting evidence found

Source Study

Thyroid Hormone Levels and Expression of Genes Involved in Regulation of Thyroid System Activity in Male Rats Exposed to Prolonged Low Temperatures, and the Effect of a Thyroid-Stimulating Hormone Receptor Antagonist on These Parameters

DOI: 10.1134/S0022093024060279