Giving old mice the drug rapamycin less often (every 5 days instead of daily) at a specific dose helps them live longer without causing diabetes-like problems, showing that we might be able to get the good anti-aging effects without the bad side effects.

Giving old mice rapamycin in their food when they're about 60 in human years helps them live longer - males lived 13% longer and females 9% longer on average.

A drug called rapamycin helped mice live longer - males lived about 9% longer and females lived about 14% longer when they started taking the drug in late adulthood.

Scientists gave mice a drug called rapamycin when they were middle-aged (around 270 days old) and found that both male and female mice lived longer compared to mice that didn't get the drug.

Giving old mice the drug rapamycin when they're about 600 days old helps them live longer - female mice lived about 14% longer and male mice about 9% longer than mice that didn't get the drug.

Scientists are trying different ways to reduce the bad side effects of a drug called rapamycin—like giving lower doses, combining it with other medicines, or taking breaks between doses—and recent findings suggest that taking breaks might help keep the good effects while reducing the bad ones.