Analysis Version
v1
History
Back to Study: Rapamycin does not compromise physical performance...
mechanistic
Analysis v1
Strong Support

In female mice that run with added weight, giving rapamycin three times a week blocks a key muscle growth signal, but giving it just once a week doesn’t keep that block going — so how often you dose matters.

9
Pro
0
Against

Evidence from Studies

Supporting (1)

9

Community contributions welcome

9

Rapamycin does not compromise physical performance or muscle hypertrophy after PoWeR while intermittent rapamycin alleviates glucose disruptions by frequent rapamycin

Randomized Controlled Trial
Animal

The study shows that giving rapamycin more often blocks a key muscle growth signal in mice that exercise, but giving it once a week doesn’t have the same effect, which matches what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Rapamycin does not compromise physical performance or muscle hypertrophy after PoWeR while intermittent rapamycin alleviates glucose disruptions by frequent rapamycin

Score: 9
DOI: 10.1101/2025.03.10.642477

Similar Assertions

In female mice that exercised with weighted wheels for 8 weeks, giving rapamycin three times a week blocked a key muscle signaling pathway, but giving it just once a week let the pathway bounce back a bit between doses — showing that how often you give the drug really changes how it works in muscles.

11
0
96%

In female mice that exercised a lot for 8 weeks, taking rapamycin — a drug that affects aging — either once a week or three times a week didn’t stop them from getting stronger or improving their stamina.

9
0
87%

Giving female mice a certain drug (rapamycin) once a week helps them run more on their own compared to giving it more often or not at all.

0
9
87%

In female mice that run a lot, taking rapamycin frequently stops them from losing fat — even though exercise usually helps them slim down.

9
0
83%

Even when mice are given a drug that blocks a key muscle growth pathway, running with added weight still makes their leg muscles bigger — showing that exercise can build muscle even when that pathway is turned down.

11
0
82%