The Claim
In adult female mice, frequent rapamycin administration at 2 mg/kg three times per week suppresses mTORC1 signaling in skeletal muscle during progressive weighted wheel running, as evidenced by reduced phosphorylation of ribosomal protein S6 in the tibialis anterior and flexor digitorum longus muscles, while once-weekly intermittent dosing fails to maintain this suppression, indicating that dosing frequency differentially affects molecular signaling outcomes.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In female mice that run with added weight, giving rapamycin three times a week blocks a key muscle growth signal, but giving it just once a week doesn’t keep that block going — so how often you dose matters.
See the scientific wording
In adult female mice, frequent rapamycin dosing (2mg/kg three times weekly) suppresses skeletal muscle mTORC1 signaling during progressive weighted wheel running, as shown by reduced phosphorylation of rpS6 in tibialis anterior and flexor digitorum longus muscles, whereas intermittent dosing (once weekly) does not maintain this suppression, suggesting differential molecular impact based on dosing frequency.
What the research says
1 studyThe study shows that giving rapamycin more often blocks a key muscle growth signal in mice that exercise, but giving it once a week doesn’t have the same effect, which matches what the claim says.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.