The Claim

Calcium alpha-ketoglutarate (CaAKG) supplementation beginning at 18 months of age was associated with a 16.6% extension in median lifespan and a 19.7% extension in maximum lifespan (90th percentile mortality) in female C57BL/6 mice in the first cohort, and a 10.5% and 8% extension respectively in the second cohort.

Source: Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
17score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

Giving female mice a supplement called calcium alpha-ketoglutarate starting in middle age helped them live longer - about 17% longer on average in one group and around 10% longer in another group, with the oldest mice also living longer.

See the scientific wording

Calcium alpha-ketoglutarate (CaAKG) supplementation starting at 18 months of age was associated with a 16.6% extension in median lifespan and 19.7% extension in maximum lifespan (90th percentile mortality) in female C57BL/6 mice in the first cohort, and a 10.5% and 8% extension respectively in the second cohort.

What the research says

1 study
  1. Study: Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

    The study tested the same supplement (CaAKG) in the same type of mice (C57BL/6) as mentioned in the claim, and found that it does extend lifespan, supporting the main idea even if the exact percentage numbers from the claim aren't shown in this abstract.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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