Giving older mice a drug called rapamycin helps keep their muscles strong and working well as they age, especially in some muscles but not others.

19

Pro

0

Against

Evidence from Studies

Supporting (1)

19

Community contributions welcome

19

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

Cohort Study

Animal

2020 Sep 9

The study tested rapamycin in old mice and found it helped preserve muscle strength and structure, especially at the nerve-muscle connection, just like the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

Score: 19

DOI: 10.1038/s41467-020-18140-1

Similar Assertions

Rapamycin might help older animals keep their muscle and stay lean by tweaking a key cell signal involved in aging.

19

9

84%

Turning on a certain signal in mouse muscles makes them age faster, causing nerve and muscle problems like those seen in old age — but this can be reversed with a drug called rapamycin.

19

0

84%

Taking rapamycin with exercise might help improve muscle strength in older people by affecting a specific cell pathway in the body.

0

73

81%

Older mice with overactive mTORC1 had higher levels of certain muscle-related amino acid processes after taking rapamycin, which might help muscles handle stress and stay healthy.

9

0

80%

In older mice with overactive muscle metabolism, giving them a drug called rapamycin changes the types of fats in their muscles — some go up, some go down — which might mean the drug helps reset how aging muscles handle fat.

9

0

77%