mechanistic
Analysis v1
Strong Support
When healthy adults get infusions of two hormones—GLP-1 or insulin—each one widens a major arm artery and boosts blood flow by about 30%. But when both are given together, they don’t widen the artery any more than just one alone, meaning they don’t add up.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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GLP-1 and Insulin Recruit Muscle Microvasculature and Dilate Conduit Artery Individually But Not Additively in Healthy Humans
Randomized Controlled Trial
Human
2018 Feb 1The study found that both GLP-1 and insulin widen arm arteries and boost blood flow when given alone, but together they don’t do more than either one alone — just like the claim says.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.