Graves disease is treated using medications and non-medication approaches together.
Mechanism
Synthesis from 2 studies
Doctors lower too much thyroid hormone by either stopping its release and making less of it with medicines, or by using radiation to kill the gland so it can't make hormone anymore. Both methods work, but one is temporary and the other is permanent.
Most probable mechanism
Excess thyroid hormone is reduced by blocking its release from the gland and stopping its production, using iodine to temporarily trap hormones inside the gland and drugs to prevent new hormone creation; if the balance is right, hormone levels stay normal even after stopping the iodine. Alternatively, radiation can destroy the gland entirely to stop hormone production forever.
Excess iodide is taken up by thyroid follicular cells through the sodium-iodide symporter, triggering a temporary block in the release of stored thyroid hormones.
Thyroid peroxidase inhibition by antithyroid drugs reduces the synthesis of new thyroid hormones, preventing replenishment of hormone stores.
When iodide suppression is removed, the balance between residual hormone release inhibition and ongoing synthesis determines whether hormone levels rebound or remain stable.
Radioactive iodine is taken up by thyroid follicular cells through the sodium-iodide symporter and emits beta radiation that causes DNA damage, leading to cell death and permanent loss of hormone-producing capacity.
Evidence from Studies
Supporting (2)
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Contradicting (0)
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Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.