mechanistic
Analysis v1
Strong Support
In mice with a specific genetic problem, hair turns gray because the stem cells that make hair color die off first—not because the color-making process itself is broken.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying
Cohort Study
Animal
2025 Jun 16In mice without a key mitochondrial gene (DGUOK), the stem cells that make hair pigment die first, causing hair to turn gray—not because the pigment-making cells can’t produce color, but because the stem cells that supply them are destroyed by toxic stress. Giving an antioxidant helped fix this.
Contradicting (0)
0
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No contradicting evidence found
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