People who have had shingles are at a higher risk of having a stroke in the first month after the infection, with this risk gradually decreasing over the next few months and returning to normal levels after one year.
Mechanism
Synthesis from 4 studies
When the shingles virus reactivates, it can travel along nerves to the blood vessels in the head, causing them to swell and get damaged. This damage makes clots more likely to form and block brain arteries, leading to a stroke. As the body clears the virus and the blood vessels heal, the risk goes back to normal after about a year.
Most probable mechanism
When the herpes virus reactivates, it can infect blood vessels in the head and neck, causing them to become inflamed and damaged. This makes it easier for blood clots to form, which can block arteries in the brain and cause a stroke. The inflammation fades over time, which is why the stroke risk drops back to normal after a year.
Reactivation of varicella-zoster virus in sensory ganglia leads to viral spread along nerve pathways to arterial walls in the head and neck
Viral presence in arterial walls triggers local inflammation, activating immune cells and damaging the endothelial lining of blood vessels
Endothelial damage promotes platelet adhesion and local thrombus formation, increasing the likelihood of arterial occlusion in cerebral vessels
Inflammation and vascular damage gradually resolve over weeks to months as viral clearance occurs and endothelial repair progresses
Less supported by current evidence, but not ruled out
The body’s strong immune reaction to the virus may make the blood more likely to clot everywhere, not just near the infected nerves. This could increase stroke risk temporarily until the inflammation settles down.
Systemic release of pro-inflammatory cytokines during acute herpes zoster infection increases levels of clotting factors and reduces natural anticoagulant activity
Altered blood flow dynamics and increased platelet activation contribute to widespread thrombotic tendency
Resolution of systemic inflammation over time restores normal coagulation balance
Evidence from Studies
Supporting (4)
Community contributions welcome
Effect of herpes zoster vaccine and antiviral treatment on risk of ischemic stroke
Association between herpes zoster infection and the risk of stroke: A population-based nested case–control study
Herpes zoster associated with stroke incidence in people living with human immunodeficiency virus: a nested case–control study
Herpes zoster and the risk of ischemic and hemorrhagic stroke: A systematic review and meta-analysis
Contradicting (0)
Community contributions welcome
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