The Claim
Exposure to 10 mM calcium increases intracellular cyclic-di-GMP levels by 2.3-fold in mid-log phase Pseudomonas aeruginosa, and elevated cyclic-di-GMP promotes biofilm formation and is associated with chronic infection in cystic fibrosis.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In the bacterium Pseudomonas aeruginosa, exposure to 10 mM calcium causes a 2.3-fold increase in cyclic-di-GMP, a signaling molecule that enhances biofilm formation and is linked to persistent infections in cystic fibrosis patients.
See the scientific wording
Calcium exposure (10 mM) increases intracellular cyclic-di-GMP levels by 2.3-fold in mid-log phase Pseudomonas aeruginosa, a signaling molecule that promotes biofilm formation and is associated with chronic infection in cystic fibrosis.
High calcium levels cause the bacteria to break down guanosine, a building block for genetic material, and use it to make a signaling molecule called cyclic-di-GMP. This molecule tells the bacteria to stop swimming and start sticking together in a slimy biofilm, which protects them from the immune system and antibiotics.
What the research says
1 studyStudy: Calcium regulation of Pseudomonas aeruginosa metabolism.
High calcium levels in the lungs of cystic fibrosis patients make Pseudomonas bacteria produce more of a sticky substance called cyclic-di-GMP, which helps them form tough biofilms that are hard to treat. The study proved this happens exactly as described.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
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