High levels of reverse triiodothyronine seen in sick people do not seem to cause the changes in thyroid hormone levels that occur during illness, because giving this molecule to healthy people did...

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Against

Evidence from Studies

Supporting (1)

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Reverse triiodothyronine does not alter pituitary-thyroid function in normal subjects.

Randomized Controlled Trial

Human

1984 Jun

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Reverse triiodothyronine does not alter pituitary-thyroid function in normal subjects.

Score: 25

DOI: 10.1210/JCEM-58-6-1184