The Claim
Elevated corticosterone levels in food-deprived rats suppress the acute increase in skeletal muscle protein synthesis during refeeding, and this suppression occurs at least partially by interfering with insulin’s anabolic signaling pathway.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In food-deprived rats, high levels of the hormone corticosterone reduce the rate of muscle protein synthesis when food is reintroduced, and this reduction occurs through disruption of insulin's signaling pathway that promotes muscle growth.
See the scientific wording
Elevated corticosterone levels in food-deprived rats suppress the acute increase in skeletal muscle protein synthesis during refeeding, and this suppression occurs at least partially by interfering with insulin’s anabolic signaling pathway.
When food returns after fasting, insulin rises and tells muscle cells to build more protein, but high levels of the stress hormone corticosterone block insulin's signal, preventing the muscle from building protein even when insulin is present.
What the research says
1 studyWhen rats haven’t eaten and then start eating again, their muscles normally rebuild quickly—but if they have too much of the stress hormone corticosterone, this rebuilding slows down because the hormone blocks insulin from doing its job. The study proved this happens.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.