The Claim

High-temperature cooking of protein- and fat-containing foods generates advanced glycation end products that induce systemic inflammation.

Source: Cardiologist Warns: These Everyday “Healthy” Foods Harm Your Heart

What the research says

Roughly balanced

Support and challenge are close. The picture may shift as more studies come in.

Supports
55score
Challenges
48score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
2 studies reviewed
In plain English

Cooking protein- and fat-containing foods at high temperatures produces compounds called advanced glycation end products that trigger systemic inflammation.

See the scientific wording

High-temperature cooking of protein- and fat-containing foods generates advanced glycation end products that induce systemic inflammation.

Why this might work

When protein- and fat-rich foods are cooked at high temperatures, harmful chemicals form and get absorbed into the body. These chemicals bind to a receptor on cells, which triggers the production of damaging molecules called reactive oxygen species. This damage turns on inflammatory pathways inside cells, leading to a body-wide increase in inflammation markers.

Verified mechanismbased on 2 studies

What the research says

2 studies

  1. Study: 1912-LB: Effect of a Four-Week Low-AGE Diet on Liver Insulin Sensitivity, Visceral Adiposity, and Inflammation in Young Adults with Prediabetes—A Randomized Controlled Trial

    When food is cooked at high heat, it creates harmful chemicals that can cause body-wide inflammation. This study showed that when people ate food cooked at lower temperatures, their inflammation levels dropped, proving that how you cook food matters for your health.

  2. Study: Effect of dietary advanced glycation end products on postprandial appetite, inflammation, and endothelial activation in healthy overweight individuals

    The study found that eating food cooked at high heat didn't cause more inflammation in the body, even though it increased some stress markers. So, it doesn't support the idea that high-heat cooking makes you inflamed.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 2 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.