For people who are overweight or obese, have heart disease but not diabetes, the biggest things that decide whether semaglutide is worth the cost are how well it prevents death and how much the drug...

In obese adults with existing heart disease but no diabetes, a weekly injection of semaglutide at 2.4 mg is associated with a lower rate of serious heart-related events such as heart attack or stroke.

For people who are overweight or obese, have heart disease but not diabetes, taking a weekly semaglutide shot might help them live healthier, longer lives — and it would cost about $73,000 for each extra year of good-quality life, according to computer modeling.

If you're obese and have heart disease but not diabetes, taking semaglutide might lower your chances of having a serious heart problem by 20%.

In adults with obesity taking semaglutide for 12 months, measurable improvements were seen in blood sugar, cholesterol, blood pressure, liver enzymes, and cardiovascular risk indicators.

In adults over 45 with heart disease and obesity but no diabetes, a weekly injection of semaglutide at 2.4 mg for about 3.3 years lowers the combined risk of heart-related death, heart attack, or stroke compared to a placebo.