The Claim

The vitamin D response element (VDRE) in the human CAMP gene promoter is evolutionarily conserved in primates but absent in mice, rats, and dogs, indicating a primate-specific mechanism of vitamin D-mediated innate immune regulation.

Source: Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D3

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
20score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

Humans and other primates have a special genetic switch that lets vitamin D boost their immune system, but mice, rats, and dogs don’t have this switch—so vitamin D works differently in them.

See the scientific wording

The vitamin D response element (VDRE) in the human CAMP gene promoter is evolutionarily conserved in primates but absent in mice, rats, and dogs, indicating a primate-specific mechanism of vitamin D-mediated innate immune regulation.

What the research says

1 study

  1. Study: Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D3

    Humans and other primates use vitamin D to turn on a germ-fighting gene called CAMP, thanks to a special genetic switch that mice, rats, and dogs don’t have. This means vitamin D boosts our immune system in a way that other animals can’t.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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