Ibrutinib, a cancer drug, blocks the DIO2 enzyme at low doses but starts killing cells at higher doses, making it less suitable than racecadotril for studying thyroid hormone effects without...

Evidence from Studies

Supporting (1)

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Novel Deiodinase 2-Selective Inhibitors—Possible Reference Substances for Regulatory In Vitro Tests for Endocrine Disruptors and Drugs Targeting T3-Dependent Processes

Computational/Algorithm Study

In Vitro

2026 Apr

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

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Source Study

Novel Deiodinase 2-Selective Inhibitors—Possible Reference Substances for Regulatory In Vitro Tests for Endocrine Disruptors and Drugs Targeting T3-Dependent Processes

DOI: 10.1177/10507256261425689