In mice, a drug called fenofibrate helps protect the brain after anesthesia, but only if the brain can burn fat for energy — when another drug blocks fat burning, the protection goes away.

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Evidence from Studies

Supporting (1)

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PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice

Randomized Controlled Trial

Animal

2023 Jan 1

The study found that a drug called fenofibrate helps protect mouse brains from anesthesia-related memory problems, but only if the brain can burn fat for energy. When another drug blocked fat burning, fenofibrate no longer worked.

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Source Study

PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice

Score: 14

DOI: 10.1515/tnsci-2022-0317

Similar Assertions

Giving mice a drug called fenofibrate before anesthesia might boost brain proteins that help burn fat for energy — like turning up the brain’s fuel-burning system for several days after the procedure.

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84%

Giving mice a specific drug before anesthesia helps them remember scary situations better after waking up.

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76%

In male mice, a long dose of a common anesthesia gas seems to lower levels of brain proteins that help burn fat for energy, and this effect lasts up to a week after the anesthesia wears off.

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71%