If you block the ATM protein in skin, the skin tans more after sun exposure because it can’t pause pigment production to fix DNA damage.

Evidence from Studies

Supporting (1)

Community contributions welcome

ATM signaling delays skin pigmentation upon UV exposure by mediating MITF function towards DNA repair mode.

Computational/Algorithm Study

Human & Animal

2023 Dec

Contradicting (0)

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

ATM signaling delays skin pigmentation upon UV exposure by mediating MITF function towards DNA repair mode.

DOI: 10.1016/j.jid.2023.03.1686

Similar Assertions

After you get sunburned, your skin temporarily stops making tan pigment because a protein called ATM redirects another protein (MITF) to fix DNA damage instead of making color.

84%

After sun exposure, a chemical tag (phosphate) is added to a protein called MITF, making it stop making pigment and instead team up with other proteins to fix DNA damage.

72%