If you block the ATM protein in skin, the skin tans more after sun exposure because it can’t pause pigment production to fix DNA damage.

Evidence from Studies

Supporting (1)

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ATM signaling delays skin pigmentation upon UV exposure by mediating MITF function towards DNA repair mode.

Computational/Algorithm Study

Human

2023 Dec

When ATM kinase is blocked, the skin makes more pigment after sun exposure because ATM normally puts the brakes on pigment production to focus on fixing sun damage. Without those brakes, pigment goes up.

Contradicting (0)

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No contradicting evidence found

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Source Study

ATM signaling delays skin pigmentation upon UV exposure by mediating MITF function towards DNA repair mode.

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DOI: 10.1016/j.jid.2023.03.1686

Similar Assertions

After you get sunburned, your skin temporarily stops making tan pigment because a protein called ATM redirects another protein (MITF) to fix DNA damage instead of making color.

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After sun exposure, a chemical tag (phosphate) is added to a protein called MITF, making it stop making pigment and instead team up with other proteins to fix DNA damage.

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72%