When women have preeclampsia during pregnancy, their immune cells called monocytes are more active and produce more inflammatory signals than those in pregnant women without this condition, suggesting their bodies are in a constant low-level inflammatory state.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

42

Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia.

Cross-Sectional Study

Human

2021 Apr

Scientists found that immune cells from pregnant women with preeclampsia are naturally more active and inflammatory than those from healthy pregnant women, like their alarm system is stuck on high. This supports the idea that preeclampsia involves long-term, low-grade inflammation.

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia.

Score: 42

DOI: 10.1016/j.jri.2021.103286

Similar Assertions

When scientists test immune cells from pregnant women with a condition called preeclampsia, adding progesterone or vitamin D to the cells in a lab seems to calm down their inflammation. It’s like turning down the volume on the body’s alarm system.

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85%

Scientists found that a lab-grown type of immune cell (called THP-1) acts like the immune cells from pregnant women with preeclampsia — it shows the same signs of inflammation. This makes it a useful tool for studying the condition without using human patients.

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