In adults with obesity who took weekly semaglutide for one year, most lost at least 5% of their body weight, with many losing 10% or more, and a smaller group losing 20% or more.
Mechanism
Synthesis from 1 study
Semaglutide works by sending signals to the brain that make you feel full faster and stay full longer, so you naturally eat less. Over time, eating less leads to weight loss without needing to change how much you move or how your body burns calories.
Most probable mechanism
Semaglutide tricks the brain into thinking you're full sooner and keeps you feeling full longer, so you eat less and lose weight.
Semaglutide binds to and activates glucagon-like peptide-1 (GLP-1) receptors in the hypothalamus and brainstem
Activation of GLP-1 receptors reduces neural signals driving hunger and increases signals associated with fullness
Reduced hunger and increased satiety lead to decreased caloric intake over time
Sustained reduction in caloric intake results in negative energy balance and loss of body weight
Evidence from Studies
Supporting (1)
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Weight loss and cardiovascular disease risk outcomes of semaglutide: a one-year multicentered study
Contradicting (0)
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Gold Standard Evidence Needed
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