In a specific part of a milk protein, both the histidine and proline building blocks help an enzyme called chymosin do its job in lab tests, and neither one is more important than the others.

4

Pro

0

Against

Evidence from Studies

Supporting (1)

4

Community contributions welcome

4

Peptide substrates for chymosin (rennin). Interaction sites in kappa-casein-related sequences located outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft.

Cross-Sectional Study

In Vitro

1987 Jun 15

The study looked at a specific part of a milk protein and found that both histidine and proline work together to help an enzyme do its job, with no single one doing most of the work — just like the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Peptide substrates for chymosin (rennin). Interaction sites in kappa-casein-related sequences located outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft.

Score: 4

DOI: 10.1042/BJ2440553

Similar Assertions

Adding a few extra pieces to a milk protein fragment makes it work way better with an enzyme, because the enzyme grabs onto it more tightly.

3

0

83%

Changing one specific building block (histidine) in a lab-made milk protein makes it harder for an enzyme to cut it, which suggests that spot is important for the enzyme to recognize its target.

4

0

80%

Some specific parts of a milk protein help it stick in the right spot on an enzyme, making it easier to cut and activate in lab tests.

4

0

79%

Scientists found two tiny pieces of a milk protein, and one of them works better than the other when interacting with an enzyme used in cheese-making because it's easier for the enzyme to grab onto it.

3

0

78%

In milk protein, certain 'Pro' building blocks act like tiny braces that hold the protein in the right shape so an enzyme can cut it cleanly at a specific spot in a lab setting.

4

0

77%