The Claim
In the MSTO-211H mesothelioma cell line, the human type 2 iodothyronine deiodinase (D2) enzyme exhibits a Michaelis constant (Km) for thyroxine (T4) of 1.3 nM, resistance to inhibition by propylthiouracil, and a half-life of approximately 30 minutes, characteristics consistent with known D2 enzyme properties.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In a specific human cancer cell line called MSTO-211H, the D2 enzyme binds thyroxine with high affinity at a concentration of 1.3 nM, is not blocked by propylthiouracil, and breaks down in about 30 minutes, matching the known biochemical behavior of the D2 enzyme.
See the scientific wording
In the MSTO-211H mesothelioma cell line, the human type 2 iodothyronine deiodinase (D2) enzyme has a low Michaelis constant (Km) for thyroxine (T4) of 1.3 nM, is resistant to propylthiouracil, and has a short half-life of approximately 30 minutes, consistent with known D2 characteristics.
The body builds a special enzyme using selenium, which binds thyroid hormone T4 very tightly and converts it into its active form. This enzyme is made in small amounts and breaks down quickly unless its destruction is blocked. When the hormone T4 is present, it speeds up the enzyme’s breakdown, but when signaling molecules like cAMP increase, the enzyme is made more or lasts longer.
What the research says
1 studyScientists studied a cancer cell line and found that the thyroid hormone-activating enzyme behaves exactly as expected: it binds its target very tightly, isn’t stopped by a common blocker, and breaks down quickly—all signs it’s the real D2 enzyme. The study confirms what was claimed.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.