The Claim
Human type 2 iodothyronine deiodinase (D2) activity in the MSTO-211H mesothelioma cell line increases approximately 30-fold under selenium-supplemented conditions compared to selenium-depleted conditions, and this enzyme is encoded by the hDio2 gene and contains selenocysteine, confirming its classification as a selenoprotein.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In the MSTO-211H mesothelioma cell line, the D2 enzyme's activity increases about 30 times when selenium is present in the growth medium, and this enzyme is produced by the hDio2 gene and contains selenocysteine, which classifies it as a selenoprotein.
See the scientific wording
Human type 2 iodothyronine deiodinase (D2) activity in the MSTO-211H mesothelioma cell line is dependent on selenium availability, with activity increasing approximately 30-fold in selenium-supplemented medium compared to selenium-depleted conditions, and this enzyme is encoded by the hDio2 gene and contains selenocysteine, confirming its classification as a selenoprotein.
The body builds a special enzyme that activates thyroid hormone only when selenium is present; without selenium, the enzyme cannot form properly and does not work. When selenium is available, it gets built into the enzyme as selenocysteine, allowing the enzyme to convert the inactive thyroid hormone into its active form. The enzyme is constantly broken down by the cell’s waste system, but when selenium is present, more enzyme is made and it lasts longer, leading to much higher activity.
What the research says
1 studyIn this cancer cell line, the enzyme that turns thyroid hormone into its active form needs selenium to work well—without it, the enzyme barely functions, but with selenium, it becomes 30 times more active. Scientists also proved this enzyme contains selenium in its structure, making it a true 'selenium enzyme'.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.