The Claim
High-sensitivity C-reactive protein (hsCRP) is a stronger predictor of coronary heart disease risk than the triglyceride-to-HDL cholesterol ratio in both Black and White adults aged 45 and older, with inflammation being the primary driver of risk in the combined biomarker profile.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In adults aged 45 and older, high-sensitivity C-reactive protein measures inflammation and predicts coronary heart disease risk more accurately than the triglyceride-to-HDL cholesterol ratio, and inflammation is the main factor driving risk when both biomarkers are considered together.
See the scientific wording
High-sensitivity C-reactive protein (hsCRP) is a stronger predictor of coronary heart disease risk than the triglyceride-to-HDL cholesterol ratio in both Black and White adults aged 45 and older, with inflammation being the primary driver of risk in the combined biomarker profile.
Chronic inflammation causes blood vessel lining to become damaged and sticky, allowing fatty deposits to build up and rupture, which blocks blood flow to the heart. This process is driven by inflammation markers like hsCRP, not by the balance of fats in the blood.
What the research says
1 studyIn adults over 45, checking inflammation levels (hsCRP) is a better way to predict heart disease risk than checking the triglyceride-to-HDL ratio, especially for Black adults — because inflammation raises risk for everyone, but the lipid ratio doesn’t raise risk for Black adults at all.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.